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Description: This meeting brings together both the developers of computational and theoretical tools for biomolecular simulations and those biological and chemical scientists interested in modeling applications. The meeting will be genuinely cross-disciplinary, with representation from most relevant areas on the organizing committee and in the invited speaker lists. Applied mathematicians and computer scientists will benefit from close interaction with the modelers — to direct their formulation of numerical and algorithmic problems and their focus on the most critical open problems. Biochemical modelers will, in turn, be exposed to recent developments in theory numerical analysis and algorithms from which their studies can benefit. Consistently, a lag has occurred between developments in the mathematical community and their transfer, implementation, and application to biological and chemical areas. An example is the development of algorithms to compute rate and extend the time scale of simulations.